[Context and motivation] AI has significantly increased its capabilities and popularity since the emergence of large language models. Especially genera-tive AI shows potential to support a variety of RE activities. [Ques-tion/problem] While the opportunities of AI in RE are being discussed, there is little reflection on the limitations and concerns of using AI. Moreover, ho-listic investigations of these aspects within the software engineering lifecycle are sparse. [Principal ideas/results] We propose a research agenda that aims to systematically investigate the potential of AI within a human-centered design (HCD) process to derive meaningful application scenarios and rec-ommendations for AI. [Contribution] In this research preview, we share ini-tial results of workshop sessions conducted with RE and UX experts to de-termine opportunities and limitations of AI – with a focus on RE activities within the HCD process – and provide insights into ongoing research activi-ties on the example of “persona agents”.